As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. 1. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. CAS #: 9004-34-6 1.6. PROSOLV SMCC - JRS Pharma Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. Combines good flow and high compactibility. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL Go to Investor Relations. Packaging: 34 x 50 kgs fiber drums. Meet our leadership team. Global Microcrystalline Cellulose Market (MCC) Size Will Reach US$ 1360 };khd5x=fr CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. PDF PRODUCT OVERVIEW: Avicel RC-591 - Signet Avicel PC 611 Microcrystalline Cellulose. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. }o]X4]. Performing this action will revert the following features to their default settings: Hooray! The most. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. A., and Smith, P. A. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P Have an order or account question? The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. 9,LL!z It is also inert and biocompatible. Home | FMC Corp Battista, O. Molecular Weight null. stream Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. Microcrystalline Cellulose (Inactive Ingredient) - Drugs.com Watch Now. Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. endobj pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. These grades have particle sizes ranging from <30 to approximately 200. PDF MATERIAL SAFETY DATA SHEET - Stobec Biologicals by FMC. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . Delivering efficient and robust formulations. Pharmacel 112 - Home - DFE Pharma 4. Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. <> MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. It is also used in plaque assays for counting. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b endstream Molecular weight: Not Applicable 1.5. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). Microcrystalline Cellulose (MCC): Benefits, Side Effects & Dosage SDS. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. ( Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. q9;v80q>jZ Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. Looking for FMC'searnings news? Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. endobj lH5JWy}DgKRR"Fs << Quick Links. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. FMC, JRS and Mingtai were estimated to hold for . Microcrystalline Cellulose - an overview | ScienceDirect Topics This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. The figure below illustrates the structural organisation of cellulose within plants. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no Microcrystalline Cellulose; Cellulose; Functions. PDF Material Safety Data Sheet - FMC However, if handling bulk powders, observance of appropriate safeguards is recommended. Well-recognized product that can do it all. No. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. endobj Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. It is available in different grades and particle sizes. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. There is a secret ingredient in your burgers: wood pulp - Quartz 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream microcrystalline cellulose melting point vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? Cellulose microcrystalline MSDS - 102331 - Merck FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. Quantity: 1 700 kgs. endobj CAS #: 9004-34-6 Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> Heavy metals, % NMT 0.001 Micro Crystalline Cellulose. Remove INCI. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . . The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. An agricultural sciences company. Microcrystalline Cellulose / Avicel PH-102. Learn about FMC's industry leading goal of net-zero emissions by 2035. PDF PRODUCT OVERVIEW: Avicel PH-200 - Signet 1 0 obj "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC Avicel PC 611 (FMC Biopolymer) | CosmeticsAndToiletries.com Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. This Microcrystalline Cellulose . Alginates from IFF are an excellent choice for consistent performance in a variety of applications. A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. The short-term limit for total inhalable dust is 20 mg/m3. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. 408. Microcystalline cellulose (WHO Food Additives Series 8) MATERIAL SAFETY DATA SHEET - Sevron <> . MSDS Ref. 102331. *r_ *?~4$ &0Y# Protect them from sunshine or rain. /Parent 3 0 R Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. stream (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O We are artists at heart and creators by nature. No. Avicel PC 611 (FMC Biopolymer) Supplied by. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. Some substance identifiers may have been claimed confidential, or may . METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. Cellulose microcrystalline. Truly distinctive drug delivery solutions. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. In extrusion-spheronisation, it is the excipient of choice. . <> It is . AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. Manufactured by: China . We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. <> No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . Microcrystalline cellulose -The oldest polymer finds new industrial uses,. SUBSTANCE IDENTIFICATION 1.1. 1 0 obj stream : 1. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. PDF Pharma Solutions Avicel Co-Processed Product Selection Guide - DuPont : 160182 Date Approved: 05/25/2010 Revision No. SAFETY DATA SHEET - Fisher Sci /Type/Page Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . BIOACCUMULATIVE POTENTIAL Superior Performance: Provides excellent water uptake and rapid swelling . Avicel CL-611 Microcrystalline Cellulose and Sodium The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. Explore how you can develop your career and bring your creative ideas to life at IFF. Avicel RC-591 & CL-611 | IMCD US In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. 2008-2023 ChemPoint. Product Name: Microcrystalline Cellulose E460 1.2. Microcrystalline cellulose - Safety Data Sheet - ChemicalBook The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. /Contents 4 0 R ETHOCEL premium ethylcellulose resins are water-insoluble polymers. : 160182. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. >> Magazine: Material safety data sheet - FMC Corporation. We know that our customers need to provide reliable and consistent products to their patients. Medium size standard MCC grade, suited for the majority of directly compressible actives. Microcrystalline Cellulose Market Share, Trend, Statistics - 2031 Microcrystalline Cellulose E460 MSDS 1. PDF (28.38 mb) 2022 Corporate Fact Sheet. q9;v80 MATERIAL SAFETY DATA SHEET. 1.3. undefined. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. Avicel Microcrystalline Cellulose Physical Properties. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. 4 0 obj With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. Microcrystalline cellulose: The inexhaustible treasure for % Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. PDF Safety Data Sheet - Accentuate The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. Microcrystalline Cellulose Excipient | Uses, Suppliers, and Avicel PH-200 microcrystalline cellulose NF, Ph. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. stream AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! (1962). MSDS Ref. stream The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. By producing Avicel . Unique functionality for a broad range of pharmaceutical applications. Microcrystalline cellulose (cas 9004-34-6) SDS(Safety Data Sheet) /MSDS The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. Product Name Cellulose microcrystalline. [FMC Study Number I92-1464]. >> This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. %PDF-1.3 There have always been two different points of view for the liquidity of MCC. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Microcrystalline cellulose is a commonly used excipient in the . xv}O2' H~KEe9>G/,:9\i Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" q86@on$^X_HuH;3` Earth Supplied Products LLC. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? Microcrystalline Cellulose (MCC) Manufacturing | Pharmaceutical Grade PDF (2.77 mb) 2021 FMC Sustainability Report. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031.
